France
Irritability, Craze, Loss of consciousness, Fits, Restlessness, Increased middle rate, Perspiration, Chill, Tremor, Mental status changes, Restlessness, Increased reflexes, Increased reflexes, Stiffness, Moving, Pain in the stomach, Diarrhea, Sweating, Increased temperature, High blood pressure. All these are signs or symptoms of serotonin syndrome. All may come usually in the first 24 hours soon after taking an o.d. of serotonin drugs.This serotonin syndrome symptoms are on cognitive stage, visceral anxious system level as well as somatic level.
Serotonin toxicity come usually after o.d. of serotonin drugs and drug combination that increase synaptic serotonin. Drugs which tend to be know to stimulate high levels of serotonin are: MAOIs, TCAs, SSRIs, SNRIs, Bupropion, Tramadol, Fentany, Oxycodone, Hydrocodone, MDMA, MDA, Pep pill, Sibutramine, Cocaine, Triptans, LSD, Panax Ginseg, Nutmed, Yohimbe, Syrian Rue, Ritonavir, Granisetron, Olanzapine, Valproate, Buspirone, Lithium, Linezolid, Dextromethorphan, Risperidone, Trypthophan, L-Dopa, Valproate, Pep pill.
Because serotonin syndrome it's not tested in the laboratory for diagnosis, signs are the one that need seen. The greatest set of criteria to utilize to diagnose serotonin toxicity is Hunter Serotonin Toxicity Criteria.Treatment for serotonin syndrome are as follows:
discontinuing drugs that produced the overdose posible and drugs that can contribute
management of serotonin antagonist (eg. cyproheptadine) for cut cases of toxicity
for agitation, muscle mass tightness and capture like movements, benzodiazepines (Valium, Ativan)
Intra venous liquids
Because serotonin syndrome is certainly not simple to diagnose, protection is required for any 5-hydroxytryptamine drugs combination which may cause serotonin toxicity.
Dunkley, EJ, Isbister, GK, Sibbritt, D, Dawson, AH, Whyte, IM, The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity, QJM 2003; 96:635-642
Prator BC. Serotonin syndrome. J Neurosci Nurs. 2006 Apr;38(2):102-5.
Ford MD, Clinical Toxicology. 1st ed. Philadelphia, Pa: WB Saunders; 2001:150, 522, 547, 550.
